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Understanding Inflammation

Home ABOUT Understanding Inflammation

What You Need To Know About Inflammation

The Common Denominator Of All Diseases

How Does Inflammation Cause Damage?

Our body is design to have its own defence and healing mechanism. Inflammation is the body’s own innate defence mechanism and forms a vital part of the healing process. It is needed to fight infection or heal wounds but left unchecked, it can lead to collateral damage and diseases.

According to leading health experts, chronic inflammation is regarded as the 21st century’s “Silent Killer.” Diseases are mostly caused by acute or chronic inflammation due to prolong faulty cell signals, from the most basic cellular level, then progressively worsen and degenerate to a larger scale that impacts the normal function of tissue and organ in our body.

Inflammation is a necessary process and natural response of the body protecting and healing itself through its immune system. When the body experiences an injury, infection or stressors, the immune system works by rushing out cells and chemicals to the inflammation site to kill off pathogens and repair damaged tissues. This process initiates our innate healing but when the body suffers constant overwhelming inflammation – due to infections, ‘injuries’ or faulty cell communication – it ceases to be beneficial and becomes harmful, leading to a number of adverse effects on human health.

HEALTHY vs. UNHEALTHY

In a healthy individual, the balanced immune system stimulates a well-modulated healing process with good cellular communication, allowing the body to progress smoothly through the phases of the healing process.

However, in the case of an unhealthy individual, there is generally poor cellular signals or communication. The underlying problem is associated with the immune system – immunodeficiency or hyper-immunity (autoimmune) where the healing instructions released by the immune system has been disrupted or desynchronized.

ACUTE vs. CHRONIC INFLAMMATION

ACUTE INFLAMMATION
Acute inflammation works by first releasing pro-inflammatory cells to fight infection, then releasing anti-inflammatory cells after the threat has been adequately addressed ( caused by wound, injuries, trauma, andinfection). Unfortunately, this natural physiological process doesn’t always function as intended, leading to the proliferation of chronic inflammation.

CHRONIC INFLAMMATION
Chronic inflammation occurs when the inflammatory response ceases to function as intended, and the immune system continues to release pro-inflammatory cells instead of the anti-inflammatory cells for repair, hence disrupting the healing process. Over time, chronic inflammation can damage healthy cells and tissues, resulting in autoimmune diseases and organ degeneration.

Chronic inflammation can have long-term and whole-body effects. Chronic inflammation is also called persistent, low-grade inflammation because it produces a steady, low-level of inflammation throughout the body, as judged by a small rise in immune system markers found in blood or tissue. This type of systemic inflammation can contribute to the development of disease.

Harvard Health Letter, Published: April, 2006

Inflammation: A Unifying Theory of Disease

  • Research is showing that chronic inflammation may be the common factor in many diseases.

  • When it comes to risk reduction it often seems as though we need to keep a running tab of things to avoid or embrace. Lay off saturated fats to keep our arteries clean. Steer clear of carbs to stave off diabetes. Stay away from smoking to prevent lung cancer. Solve the sudoku puzzle to outwit dementia. And exercise, exercise, exercise! Wouldn’t it be nice if there were a one-stop approach to health just as there is to shopping?

  • Although there may never be such a single path mounting evidence suggests a common underlying cause of major degenerative diseases. The four horsemen of the medical apocalypse — coronary artery disease, diabetes, cancer and Alzheimer’s — may be riding the same steed: inflammation.

  • Research on inflammation has created a shift in medical thinking. For two millennia it has been viewed mainly as a necessary even beneficial response to illness or injury. But now both observational studies and laboratory research are indicating that inflammation can be more of a bane than boon, the common, causative factor in many diseases.

When The Cause Of Inflammation Is Not Removed

Chronic inflammation often begins with the same cellular response, but morphs into a lingering state that persists for months or years when the immune system response fails to eliminate the problem. Alternatively, the inflammation may stay active even after the initial threat has been eliminated. In other cases, low-level inflammation becomes activated even when there is no apparent injury or disease. Unchecked, the immune system prompts white blood cells to attack nearby healthy tissues and organs, setting up a chronic inflammatory process that plays a central role in some of the most challenging diseases of our time, including rheumatoid arthritis, cancer, heart disease, diabetes, asthma, and even Alzheimer’s.

In another word, the inflammation process is suppose to fight off bacteria and at the same time remove any dead cells and tissue and provide a fresh foundation for new cells and tissues to form and restore function.

Instead prolonged inflammation also causes continue removal of cells and tissues including the healthy cells and tissue, known as autoimmune conditions where the body’s immune system starts to attack the host.

 

SOURCE: Robert H. Shmerling, MD, Associate Professor of Medicine at Harvard Medical School, Clinical Chief, Division of Rheumatology at Beth Israel Deaconess Medical Center, and Senior Editor at Harvard Health Publishing. 29 pages (2018)

Chronic Disease Development

Causes Of Inflammation:

INJURY

INFECTION

POLLUTION

STRESS

UNHEALTHY DIET

Unless there is an underlying genetic problem, there is always a stimulating factor which triggers the inflammation response and if unresolved, it becomes chronic.

Diseases Related To Chronic Inflammation:

Collectively called Chronic Inflammatory Diseases (CIDs)
  • Autoimmune disease
  • Rheumatoid Arthritis (RA)
  • Multiple sclerosis (MS)
  • Psoriasis…etc.
  • Asthma and Allergy
  • Crohn’s disease
  • Inflammatory Bowel Disease
  • Cardiovascular Disease and Arteriosclerosis
  • Stroke
  • Diabetes and Insulin resistance
  • Neuron degeneration
  • Alzheimer's Disease
  • Osteoporosis
  • Cancer

How Chronic Systemic Inflammation Affects The Body

Inflammation is the root of practically all known chronic health conditions.
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    GI TRACT
    Chronic inflammation damages our intestinal lining and can lead to issues such as GERD, Crohn’s disease and Celiac disease.

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    BONES
    Inflammation interferes with the body’s natural ability to repair bone mass, increasing the number of fractures and leading to conditions like osteoporosis.

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    KIDNEYS
    Inflammatory cytokines restrict blood flow to the kidneys. It can lead to complications like edema, hypertension, nephritis and kidney failure.

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    LIVER
    Build-up of inflammation leads to an enlarged liver or fatty liver disease. Increased toxic load build-up in the body.

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    SKIN
    Chronic inflammation compromises the liver and kidneys, resulting in rashes, dermatitis, eczema, acne, psoriasis, wrinkles and fine lines.
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    BRAIN
    Pro-inflammatory cytokines cause autoimmune reactions in the brain, which can lead to depression, autism, poor memory, Alzheimer’s disease and MS.

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    THYROID
    Autoimmunity as a result of inflammation can reduce total thyroid receptor count and disrupts thyroid hormone function.

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    CARDIOVASCULAR
    Inflammation in the heart and arterial and venous walls contribute to heart disease, strokes, high blood sugar (diabetes) and anemia.

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    LUNGS
    Inflammation induces autoimmune reactions against the linings of airways. Can result in allergies and asthma.

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    MUSCLE
    Inflammatory cytokines can cause muscle pain and weakness. It can manifests as carpal tunnel syndrome, or polymyalgia rheumatica to name a few.

The Immune System & Healing Process

The immune system is a complex system and widely known for protecting our body by fighting off any foreign invaders such as bacteria and viruses. While the immune system is defending our body, it undergoes an inflammatory process. This process is only one small side of what it’s truly capable of performing.

Our immune system not only fights foreign invaders, but it is also responsible for our daily metabolism of removing dead cells/tissues and regulating stem-like cells in the body to create new cells. In cases where cells or tissues are damaged such as a wound or liver disease, the immune system is stimulated to undergo inflammation to remove any dead or unwanted cells followed by triggering a proliferation stage known as repair stage where the immune system activates the stem-like cells to regenerate the damaged cell and tissues. The final stage of the immune system is remodeling the wound undergoing repair to ensure no scars are left behind after repair. The process is known as the healing process which is entirely regulated by our immune system.

The healing process is continuously happening in our body as millions of cells are being replaced daily in the body. When we have a healthy and balanced immune system, our body can easily fight off any foreign invaders, quickly and effectively repair or replace any damaged cells or tissues in the body to restore optimal functions.

However, over the past 30 years, we have seen an escalation of diseases such as diabetes, cancer, autoimmune conditions (lupus, leukemia, multiple sclerosis, psoriasis, allergy, etc.), immunodeficiency conditions (unable to fight infections or trigger the immune system to start the healing process) and chronic inflammation. All these are the result of an unbalanced immune system caused by mostly lifestyle such as consumption of processed foods, exposure to chemical, drugs, stress, insomnia, smoking, drinking, and other negative lifestyle choices.

Three different types of unbalanced immune system:

  1. Desynchronization of cellular signaling – when the communications between the cells have been damaged or altered, the signals are either lost or over-amplified, leading to a disruption of the healing process.
  2. Autoimmune – when the immune system is hyperactive and overreact causing the immune system to attack the host’s healthy cells mistakenly. E.g., multiple sclerosis, psoriasis, lupus
  3. Immunodeficiency – when the immune system’s ability to trigger the healing process is hindered.

There is currently no medication available in conventional medicine to regulate an unbalanced immune system back to a balanced state. Through years of research, BLOOMED has found the solution to help regulate the immune system through cellular therapy. Using your immune system from whole blood, we can recreate a balanced immune system blueprint and reintroduce back into your body to modulate the immune system.

HOW OUR BODY

The HEALING PROCESS is a complex and dynamic process regulated by the immune system. The immune system not only fights off bacteria but also regulates the entire healing process, which can be divided into 4 distinct phases – TRIGGER, INFLAMMATION, REPAIR AND RESTORE.

TRIGGER

STIMULATING FACTOR (Injury / Wound):

Allergen
Radiation
Infection
Autoimmunity
Chemotherapy

 

The fundamental treating method of ISC (Immune Signaling Cells) is to regulate the immune system by down regulating auto immunity to stop the immune system to attack the host or up regulate immune deficiency so the body can identify and attack any harmful subjects to protect the host. By first regulating the immune system with ISC, an all out investigation and testing should be conducted with patient to find the source of stimuli that is triggering the inflammation process.

RESTORE (REMODELING)

 

 

 

Tissue continues to remodel over time until the function is restored

Why is BloomMed’s ISC Needed?

This is where BLOOMMED’s innovative solution comes in with its revolutionary ISC therapy consisting of anti-inflammatory monocytes which are the key to address the inability of pro-inflammatory macrophage to turn into the anti-inflammatory macrophage. This step is crucial to resume the healing process for the body. ISC also produces numerous cytokines and growth factors that will benefit the local cells and enhance the coordinated healing and repair process to efficiently prevent the disease or wound progression. ISC (Immune Signaling Cells) basically detects and amplify the optimal cell signal and then trigger the body’s self-healing process, while also reinforcing the tissue repair and regeneration simultaneously.

Our Unique Difference

What Sets ISC Therapy Apart From The Rest?

Although stem cell treatment is hugely marketed and vastly popular, very little is known on its exact therapeutic mechanism. It is a given that it will only benefit the patient if the healing process can progress into the repair stage before the stem cells could be of any use. However for patients with chronic inflammation or lacking the stimulus to start the healing process within the immune system, injecting stem cells without understanding the entire process will show very minimal results. The stem cells would not be able to perform its job if the healing process is inhibited.

ISC therapy is different because we understand the healing process entirely and the therapy is specifically designed to ensure firstly the modulation of the immune system would provide the right cellular signaling for the progress to the repair stage is initiated and maximized. The ISC solution is much more effective because compared to conventional therapies, it targets the source of the issue. This, in turn, would optimize the efficacy of the stem cells.

UNIQUE DIFFERENCE

ISCs are cultured safely in a closed loop system

  • No hazardous chemicals or animal bovine serum that could cause rejection if reinfused into the body.
  • Cultured in closed sterile environments and are examined with accredited laboratories.
UNIQUE DIFFERENCE

Autologous Derived

  • Produced without genetic manipulation or cloning
  • yet the unique culture process ensures the maximum effectiveness of the therapy utilizing only your own cells.
UNIQUE DIFFERENCE

Evidence-based and real-world application

  • ISC therapy is safely administered in compliance with standard health regulation.
  • No adverse effects reported but all have exhibited benefits and improvements.
UNIQUE DIFFERENCE

Safe and simple extraction process

  • Up to 250mL of blood is collected from the patient for treatment.
  • Culture process takes only two to four days after which reinfusion is possible.
  • The extraction process is akin to blood donations and treatment would be possible in a matter of days.
  • The fast turn-around time is virtually impossible to achieve with other stem cell treatment options.